James Kneller is one of the nation’s leading heart rhythm specialists. Dr. Kneller is certified by the American Board of Internal Medicine (ABIM) in clinical cardiac electrophysiology, cardiovascular disease, and internal medicine. As a Fellow of the Heart Rhythm Society (FHRS) and Certified Cardiac Device Specialist (CCDS), Kneller provides comprehensive patient care, combining best medical practice with invasive procedures using state-of-the-art technologies to treat heart rhythm disorders.
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His procedural skills encompass both device implantation and management, and catheter ablation. His device procedures include pacemakers, implantable cardiac defibrillators (ICDs), subcutaneous ICDs (S-ICD), and cardiac resynchronization therapy (CRT) with both pacemaker (CRT-P) and defibrillator (CRT-D) systems. Dr. Kneller performs catheter ablation of supra-ventricular tachycardia (SVT), atrial flutter, atrial fibrillation (AF), ventricular tachycardia (VT), and premature ventricular contractions (PVCs).
Mechanisms of atrial fibrillation and antiarrhythmic drug therapy evaluated by mathematical modeling.” This work included two manuscripts published in Circulation Research, entitled: “Cholinergic atrial fibrillation in a computer model of a 2-dimensional sheet of canine atrial cells with realistic ionic properties” (Circ Res. 2002), followed by “Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model” (Circ Res. 2005).
In these studies, Kneller developed the first mathematical model of a sustained arrhythmia, and subsequently used the model to solve the mechanism of atrial fibrillation termination by class I antiarrhythmic drugs, which to date have been both the most successful, but also the most poorly understood class of atrial fibrillation (AF)-terminating drug in clinical practice.